Several miRNAs, such as miR-25-3p, miR-130b-3p, and miR-425-5p, are transferred by exosomes to colorectal cancer (CRC) cells via the CXCL12/CXCR4 axis to activate the PI3K/AKT signaling pathway to induce the M2 polarization of macrophages, which increases EMT and vascular endothelial growth factor (VEGF) secretion in CRC cells [20]. This evidence concerns the gene CXCL12 and colorectal carcinoma.