Additionally, mahanine, which belongs in the DNA methyltransferase inhibitor (DNMTi) family, induces proteasomal degradation of DNMT1 and DNMT3B via AKT inactivation in prostate cancer cells, thereby promoting RASSF1A promoter demethylation and restoration of its normal expression [135]. The gene discussed is AKT1; the disease is Familial prostate cancer.