Interestingly, the antiproteinuric effect of the combined treatment may be reminiscent of the data collected by our group from BTBR ob/ob mice with diabetic nephropathy, in which the addition of cAng-(1-7) to ACE inhibitor therapy had a superior effect to ACE inhibitor alone, thanks to better preservation of podocytes and an improvement in glomerular endothelial damage [19]. Here, ACE is linked to diabetic kidney disease.