However, increased PPARγ expression in bladder cancer through its suppression of NF-κB leads to the phenotype of immune cold tumors, which do not respond to immunotherapies and are characterized by low immune-cell trafficking, impaired T-cell activation, an abundance of myeloid-derived suppressor cells, and Tregs that release immunosuppressive cytokines [499]. The gene discussed is PPARG; the disease is urinary bladder cancer.