PPARG and neoplasm: Even before reaching maturity at around 30 days of age, female mice displayed palpable tumor masses. These results indicate that once an initiating event has taken place, increased PPARγ signaling exacerbates mammary-gland tumor development [165]; this is similar to the observed situation of accelerated colon cancer formation in APCMin/+ mice treated with thiazolidinediones described before [122,123].