Ubiquitin-specific protease 22 (USP22) stabilizes PPARγ due to deubiquitination, which increases acetyl-CoA carboxylase (ACC) and ATP citrate lyase (ACLY) expression and induces de novo lipogenesis as a risk factor for hepatocellular carcinoma (HCC). The gene discussed is USP22; the disease is hepatocellular carcinoma.