VEGFA and cancer: Furthermore, as a general characteristic of cancer metabolism, the rapid growth of tumors results in hypoxia and the stabilization of hypoxia-inducible transcription factors (Hif) [380,381], which induce or repress the expression of downstream target genes, with relevance to cancer growth, e.g., VEGF [382], WT1 [383], PPARα [384], glucose transporters, and many others (reviewed in [385]).