PPARG and thyroid gland disorder: PPARγ has been identified as a critical modifier in thyroid carcinogenesis using transgenic animals harboring a knock-in dominant-negative mutant thyroid hormone receptor beta (TRbetaPV/PV mouse), which spontaneously develop follicular thyroid carcinoma. TRbetaPV/PV mice were crossed with PPARγ +/− mice, and it was shown that thyroid carcinogenesis progressed faster in animals with PPARγ haplo-insufficiency.