Elevated platelet counts were reported to be associated with tumor cells with greater metastatic ability [32], through secretion of multiple cellular growth factors such as platelet-derived growth factor, vascular endothelial growth factor, transforming growth factor beta, platelet factor 4, and inflammatory mediators, which are responsible for stimulating the growth and angiogenesis of tumor cells [33,34]. This evidence concerns the gene PF4 and neoplasm.