Given the diminished glycolysis [238] and mitochondrial ETC activity that occurs in PD dopaminergic neurons and in other neurodegenerative disorders characterized by dysfunctional MQC, one important question is whether glucose and fatty acids are still capable of supplying the ATP required for the proteolytic processes that remove damaged and misfolded proteins such as α-synuclein. The gene discussed is SNCA; the disease is Parkinson disease.