PLCB2 and breast cancer: In the trachea, the stimulation of BC with Tas2R agonists, e.g., denatonium and the formylated peptide f-MKKFRW, triggers a PLCβ2-mediated release of Ca2+ from inositol 1,4,5-trisphosphate (IP3)-sensitive Ca2+ stores, resulting in Trpm5 channel activation and acetylcholine (ACh) release from BC [9,10,15].