KCNJ8 and migraine disorder: Collectively, the interpretation regarding subunit contribution to headache is difficult as rodent and, to some extent, human data suggest that glibenclamide may inhibit headache (hypersensitivity in rodents) to some degree, without the relevant effect on the vascular Kir6.1/SUR2B channel, which is the proposed mediator of levcromakalim-induced migraine [22].