Thereafter, we assessed that IL-8, secreted in the conditioned medium collected from the AGEs-stimulated CAFs, acts in a paracrine manner through the cognate receptors CXCR1/2, empowering the acquisition of a spindle-like morphology and the actin polymerization in MDA-MB-231 breast cancer cells. The gene discussed is CXCL8; the disease is breast cancer.