For example, Ishimoto et al. analyzed three gastric cancer lines (MKN28, AGS, and KATOIII) and two colorectal cancer lines (HT29 and HCT116) to reveal that the expression of the CSC marker CD44 and its variant (CD44v) was correlated with an increased antioxidant efficiency in response to H2O2 treatment that was abrogated by CD44 depletion with RNAi. This evidence concerns the gene CD44 and colorectal cancer.