Of note, measurements with 2′,7′-dichlorofluorescein diacetate (DCF-DA) revealed that the CD13+/CD133+ and the CD13+/CD90− fractions of the HCC cells contained lower basal levels of cytosolic and mitochondrial ROS than the CD13−/CD133+ and CD13−/CD90+ fractions and were also characterized by an increased ROS scavenging ability in response to exogenous H2O2 administration. The gene discussed is ANPEP; the disease is hepatocellular carcinoma.