It has to be noted that, while the status of NRF2 was not directly investigated in these studies, GCLM, GPX2, GPX4, PRX1, and the xCT system are well-recognized targets of NRF2, suggesting that the increased expression of redox regulators in CSCs might be caused by NRF2 overactivation, similarly to what is observed in non-stem cancer cells [42]. This evidence concerns the gene NFE2L2 and cancer.