Later, the same workgroup showed that mitochondrial biogenesis is associated with an increase in the expression of two major anti-inflammatory genes, IL10 and IL1Ra, through HO-1/CO and NRF2 redox regulation in mitochondria from human-hepatoma-derived HepG2 cells and in vivo liver cells [58]. Here, NFE2L2 is linked to hepatocellular carcinoma.