We also showed that M1- and K63-ubiquitins are exclusively colocalized with thick bundles of TDP-43 from sALS patients [22] and tau neurofibrillary tangles from Alzheimer’s disease patients [23], whereas K48-ubiquitin was detected in both tiny and thick inclusions. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.