SMAD4 and pancreatic neoplasm: The hamster BOP model closely resembles the stages in human pancreatic cancer as it causes pancreatic intraepithelial neoplasia (PanIN), a premalignant stage of pancreatic cancer that progresses to severe pancreatic ductal adenocarcinoma as observed in humans, including harboring similar genetic mutations such as in K-ras, CDKN2A, and SMAD4 [16].