For example, the maintenance of the expression of KCNQ1 was associated with a significant survival advantage in human colorectal cancer patients with stage IV metastatic disease [44], and very recently it was reported that KCNQ1 was a major CRC prognostic predictor classifier as CRC patients with stage II and stage III CRC who maintained expression of KCNQ1 showed a much stronger disease-free survival (DFS) [45]. This evidence concerns the gene KCNQ1 and metastatic neoplasm.