In summary, we demonstrated that in comparison to the highly immunodeficient B-NDG mice, ZZU001 hamsters with the loss of IL2RG function alone (therefore much less immunodeficient than B-NDG mice) support better human pancreatic cancer cell engraftment and multiple organ metastasis and serve as an improved host for human pancreatic cancer engraftment. Here, IL2RG is linked to pancreatic neoplasm.