Regarding PCa, IGF-1 secreted by periprostatic adipose mass was recently shown to reduce malignant cell susceptibility to docetaxel [30]; our findings not only confirm the ability of adipocytes to modulate cancer chemoresistance but also open the possibility that other adipocyte-released insoluble factors are crucially involved in the development of treatment-unresponsive carcinomas. The gene discussed is IGF1; the disease is carcinoma.