In addition, the fractions of M2 macrophages, CD4 memory resting T cells, resting NK cells, monocytes, neutrophils and M1 macrophages were remarkably higher in the AD group compared with the HC group, while the fractions of memory B cells, CD8 T cells, plasma cells, activated mast cells, activated NK cells and follicular helper T cells were lower in the AD group (Figure 3B,C). This evidence concerns the gene CD4 and Alzheimer disease.