By detecting the effect of ENO2 on the expression of EMT markers in CRC cells, we observed that ENO2 was positively correlated with the protein levels of several typical mesenchymal phenotype markers, such as SLUG and N-cadherin, and negatively correlated with the protein levels of the epithelial phenotype markers OCLN and E-cadherin. This evidence concerns the gene CDH2 and colorectal carcinoma.