In addition, in CF sweat, the decreased levels of CFTR interactors, e.g., ERM proteins (EZR, MSN) or filamins, plus the under-expression of all the protein constituents of the desmosome highlighted: (i) the defects in CFTR homeostasis and membrane stability as well as cell-cell adherence and membrane integrity of the eccrine gland cells, (ii) the potential of sweat analysis to remotely monitor some aspects of CF pathophysiology in other epithelia. The gene discussed is MSN; the disease is cystic fibrosis.