Although HNSCC cells are already characterized by enhanced glycolysis in normoxic conditions [44], the mitochondrial function impairment due to the FANCA mutation further favours the switch to anaerobic metabolism, as demonstrated by the increment of LDH activity and the anaerobic glycolysis yield in OHSU-S91 compared to OHSU-FAcorr cells. This evidence concerns the gene FANCA and head and neck squamous cell carcinoma.