Higher percentages of altered FANC genes have been found in HNSCC patients unaffected by FA [15,16,17,18], as well as in various cancer types, both sporadic and hereditary: among them, breast and ovarian cancer with mutations occurring most likely in FANCA, FANCS/BRCA1, and FANCD2/BRCA2 genes [19,20]. The gene discussed is FANCA; the disease is cancer.