The next functional ligands to be described were galectin-3 (Gal-3), critical to inhibit T cell activation and CD8 cytotoxic T cell functions [37,38,39,40], the liver-secreted protein fibrinogen-like protein 1 (FGL1), critical for tumor immune evasion mechanisms in response to anti-PD-1/anti-PD-L1 treatments [9,37,41,42,43], and the DC-specific Intercellular adhesion molecule-3-grabbing non-integrin family member (LSECtin) in melanoma cells, inhibiting cyclin-dependent kinases [44]. The gene discussed is PDCD1; the disease is melanoma.