LAG-3 is expressed by many T cell subsets, including: CD4 T helper cells, cytotoxic CD8 T cells, activated T cells, NK T cells, effector CD4 T cells, regulatory T cells, CD8 tumor-infiltrating lymphocytes and tumor-infiltrating antigen-specific CD8 T cells [4,16,17,18,19,20,21,22,23,24,25,26,27]. This evidence concerns the gene CD4 and neoplasm.