To perform this process, cancer stem cells present activated signaling cascades that regulate transcription factors such as SNAIL (snail family transcriptional repressor 1), SLUG (snail family transcriptional repressor 2), ZEB1 (zinc finger E-Box binding homeobox 1), and ZEB2 (zinc finger E-Box binding homeobox 2) [59,60,61,62]. The gene discussed is ZEB1; the disease is cancer.