PIEZO1 and cyclic hematopoiesis: This study aimed to determine the involvement of Piezo1 in the development of the disease in a rat model of CH-PH after 1 week (1W-CH) and 3 weeks (3W-CH) of CH and to compare the activity of Piezo1 channels in PASMCs and PAECs and their effect on calcium signaling, membrane potential, and the eNOS phosphorylation pathway.