To investigate the depletion efficacy of neutrophils in the hMRP8-ATTAC model in a mammary tumor setting, we orthotopically transplanted mammary tumor pieces, derived from the transgenic K14-cre;Cdh1F/F;Trp53F/F (KEP) mouse mammary tumor model [20,29], in the mammary fat pad of hMRP8-ATTAC mice. The gene discussed is KRT14; the disease is breast cancer.