Biologically active levels of TGF-β2 are higher in the aqueous humor of eyes with primary open angle glaucoma than in those with primary angle closure glaucoma and uveitis-associated secondary glaucoma [233], indicating that increased levels of total and mature TGF-β2 may play an important role in the pathogenesis of primary open angle glaucoma. Here, TGFB2 is linked to primary angle-closure glaucoma.