Recently, Tosi et al. measured the protein concentration of active TGF-β1, TGF-β2, and TGF-β3 at baseline and after intravitreal anti-VEGF-A injection in the aqueous humor of patients with wet AMD: in the baseline group, the aqueous humor concentration revealed the preponderance of TGF-β2 over TGF-β3 and TGF-β1 [189]. This evidence concerns the gene TGFB1 and wet macular degeneration.