Hyaluronan synthase 2 (HAS2) is the enzyme responsible for synthesizing hyaluronic acid, and hyaluronidase-1 (HYAL1) is the enzyme that cleaves high molecular weight hyaluronic acid, which is anti-tumorigenic, into smaller molecular weight tumor promoting fragments known to promote angiogenic, tumorigenic, and migratory phenotypes in many different cancers [15,16]. Here, HYAL1 is linked to cancer.