Here, we identified a gene set of potential prognostic biomarkers correlated to survival outcome (using two different regularizers, EN and TCox) and enriched gene ontologies of ccRCC patients (COPS7B, DONSON, SEC61A2, SNRPA1, SORBS2, GTF2E2, HAUS8, PRH2, ZNF18, FBXO5, SMC4, PRC1, SLC34A1, SLC12A3, KIF, TPX2, GTSE1, SLC14, AQP, TTK, NEK2, and NUF2). Here, ZNF18 is linked to nonpapillary renal cell carcinoma.