Here, we identified a gene set of potential prognostic biomarkers correlated to survival outcome (using two different regularizers, EN and TCox) and enriched gene ontologies of ccRCC patients (COPS7B, DONSON, SEC61A2, SNRPA1, SORBS2, GTF2E2, HAUS8, PRH2, ZNF18, FBXO5, SMC4, PRC1, SLC34A1, SLC12A3, KIF, TPX2, GTSE1, SLC14, AQP, TTK, NEK2, and NUF2). This evidence concerns the gene COPS7B and nonpapillary renal cell carcinoma.