Here, we identified a gene set of potential prognostic biomarkers correlated to survival outcome (using two different regularizers, EN and TCox) and enriched gene ontologies of ccRCC patients (COPS7B, DONSON, SEC61A2, SNRPA1, SORBS2, GTF2E2, HAUS8, PRH2, ZNF18, FBXO5, SMC4, PRC1, SLC34A1, SLC12A3, KIF, TPX2, GTSE1, SLC14, AQP, TTK, NEK2, and NUF2). The gene discussed is PRH2; the disease is nonpapillary renal cell carcinoma.