CXCL2 and neoplasm: In HT-29 and HCT116 CRC cells, tumor growth and angiogenesis was promoted by guanine the nucleotide-binding protein alpha-13 (GNA13) via upregulation of CXCL2 through the activation of the PLC-DAG-PKC-NF-kB signaling pathway (Figure 8) [168].