Another recent in vivo study reported that PGE2 can also activate colonic cancer stem cell (CSC) proliferation and liver metastasis via multiple signaling pathways, such as NF-κB, phosphoinositide 3-kinase (PI3K)-AKT and MAPK, by binding to its EP2 cell surface receptors [125]. This evidence concerns the gene NFKB1 and colonic neoplasm.