STAT3 and colorectal carcinoma: Moreover, the IL-6-activated STAT3 in TME can cause the malignancy of CRC via transcriptional (promoter binding) and post-translational (K116 deacetylation) upregulation of Fructo-Oligosaccharide-like 1 (FOSL1) and FOS-related Antigen 1 (FRA1) [63].