Another study demonstrated that excess circulation of CXCL1 leads to a reduction in an extracellular matrix tumor-suppressor protein fibulin-1 through NF-κB/Histone Deacetylase 1 (HDAC1) epigenetic regulation, which facilitates the invasion and metastasis of CRC cells [154,155]. This evidence concerns the gene NFKB1 and colorectal carcinoma.