CXCL2 and colorectal carcinoma: They have also reported that CXCL2 downregulation induces apoptosis and inhibits proliferation of tumors, which in turn downregulates the expression of a wide range of metastasis-promoting factors, including Secreted Protein and Rich in Cysteine (SPARC), Epidermal growth factor-containing fibulin-like extracellular matrix protein (EFEMP) and COX2 in CRC [172].