CXCL1 also triggers the activation of MyD88-RAS-rapidly accelerated fibrosarcoma (RAF) kinase signaling, which in turn aids in the activation of mitogen-activated extracellular signal-regulated kinase (MEK)-ERK-Ets-like protein (ELK) pathways that leads to CRC [157] (Figure 7). The gene discussed is MAPK1; the disease is colorectal carcinoma.