TNF and Insulin resistance: Dysregulation of pro-inflammatory adipocytokines production in WAT such as plasma leptin, tumour necrosis factor-a (TNF-α), and non-esterified fatty acid concentrations with the downregulation of anti-inflammatory adiponectin can lead to infiltration of macrophages into WAT causes chronic, low-grade inflammation that closely related to insulin resistance and obesity- DM2 [123,148].