Okada, Mizuno, Sibayama, Hosokawa and Miyashita [133] demonstrated that diets of Undaria pinnatifida lipids (UL) containing fucoxanthin and its metabolites combined with scallop phospholipids (PL) capsules; high in n-3 polyunsaturated fatty acids caused a substantially increase the UCP1 expression (2.15-fold higher compared to the control group), indicating that UL and PL work synergistically to reduce obesity and exhibit greater anti-obesity effect. This evidence concerns the gene UCP1 and obesity due to melanocortin 4 receptor deficiency.