The clinicopathological data showed a shorter duration of nephropathy, more KIM-1 positive area and thicker TBM in the Isotype and the Mixed group than in the None group (P < 0.05); meanwhile, higher levels of proteinuria and lower levels of serum albumin exhibited in the Mixed group than in the Isotype group and the None group (P < 0.05). The gene discussed is ALB; the disease is kidney disorder.