EpCAM aptamer-modified PEG-cationic liposomal NPs loaded with oncogenic miR-139-5p mimics exert anti-tumor effects through electrostatic adsorption of miR-139-5p mimics, long circulation time in vivo with the help of PEG and targeted binding of EpCAM to CRC cells (Fig. 7) [168]. This evidence concerns the gene EPCAM and colorectal carcinoma.