Moreover, in order to confirm the positive correlation between the expression of HK2 and p-Akt1, Fibronectin and MMP9 in human ovarian cancer tissues, serial sections of human ovarian cancer tissues (n = 25) were immunostained with antibodies specific for HK2, p-Akt1, fibronectin and MMP9 (Fig. 4E). This evidence concerns the gene FN1 and ovarian cancer.