Furthermore, in order to determine whether the alteration of Akt1 and p-Akt1 expression under HK2-modified was responsible for the changing of cell growth, migratory and invasive capacity in human ovarian cancer cells, MK2206, an inhibitor of Akt1/p-Akt1, was used to block the elevated expression of Akt1 and p-Akt1 in HK2 overexpressed SKOV3 cells. Here, AKT1 is linked to ovarian carcinoma.