To explore the potential EMT-related proteins that are probably mediated by HK2 in human ovarian cancer cells to enhance cell migratory and invasive, real-time PCR and western blotting were applied to verify the expression of key EMT-related proteins in SKOV3-GFP, SKOV3-HK2, A2780-shCtr and A2780-shHK2 cells. Here, HK2 is linked to ovarian cancer.