As shown in Fig. 4, the positive correlation between HK2 and p-Akt1 (Fig. 4F, r = 0.4979, p = 0.0105), fibronectin (Fig. 4G, r = 0.1850, p = 0.0320) and MMP9 (Fig. 4H, r = 0.3821, p = 0.0020) in these human ovarian cancer tissues was confirmed by using Pearson correlation analysis. Here, HK2 is linked to ovarian cancer.