Although the expression of HK2 in OV (ovarian serous cystadenocarcinoma) was not so correlation between the prognosis of patient, however, the expression of HK2 was associated with a poorly prognosis of patient in CESC (cervical squamous cell carcinoma and endocervical adenocarcinoma), KICH (kidney Chromophobe), SARC (sarcoma), PCPG (pheochromocytoma and paraganglioma), LIHC (liver hepatocellular carcinoma), LUAD (lung adenocarcinoma) and LGG (brain lower grade glioma, Fig. 6A and B, TIMER 2.0) [19]. Here, HK2 is linked to hereditary pheochromocytoma-paraganglioma.