Rg1 (20 mg/kg) ameliorated memory impairment and depression-like behavior via downregulation of complexin-2 (CPLX2), synaptosomal-associated protein 25 (SNP25) and synapsin-2 (SYN2) expression in the hippocampus of mice [67]. This evidence concerns the gene CPLX2 and major depressive disorder.