The labour process is smooth, and the possibility of cerebral haemorrhage caused by labour injury was small. Two cases of NS due to FAF1 gene mutation can lead to intracranial vascular malformation [16, 17] (Table 2); Because RAF1 plays an important role in vascular matrix production [18] and vascular immune protection [19], mutations in RAF1 gene can lead to cerebral vascular malformations, resulting in cerebral haemorrhage. Since our case had multiple cerebral haemorrhage, the possibility of cerebrovascular malformation was small. This evidence concerns the gene RAF1 and hemorrhage.