To decipher the variations of LY6G6D expression in different histological subtypes of colorectal carcinoma, we examined the gene expression profiles in the TCGA database, which includes samples of colon adenocarcinoma (COAD, N = 478) and rectal adenocarcinoma (READ, N = 166), respectively. The gene discussed is LY6G6D; the disease is colon adenocarcinoma.