The DOX-JQ1@Gel-treated and contralateral tumor grew slowly within 1 week of dosing according to bioluminescence imaging and tumor growth curves shown in Fig. 5B, C. The tumor size significantly decreased in DOX-JQ1@Gel-treated and opposite tumor sites (Fig. 5D) and corresponding enhanced infiltration of CD4+CD8+ T cells compared with those of untreated mice (Fig. 5F). This evidence concerns the gene CD4 and neoplasm.