In addition, a pan-pancreatic cancer cell analysis of CCLE database and iRegulon analysis suggested that S100A14-FOXL1-PD-L1 pathway may be a potential signal axes inhibiting the activation of CD8 + T cells, which was also verified by immunohistochemical results of PUMCH cohort. The gene discussed is FOXL1; the disease is familial pancreatic carcinoma.