Moreover, the transcription factor was also predicted to regulate the expression of PD-L1 (Fig. 8H), and it was significantly positively correlated with S100A14 (Fig. 8I), suggesting that the S100A14-FOXL1-PD-L1 pathway may be one of the main signal axes regulating the immune desert microenvironment of PC induced by S100A14. The gene discussed is FOXL1; the disease is pachyonychia congenita.