Firstly, a pan-cancer analysis of S100A14 revealed that PC experienced one of the most remarkably increase of S100A14 expression among all types of cancer (Fig. 8A), which was also confirmed by qRT-PCR and western blot in pancreatic normal ductal cell line and pancreatic cancer cell lines (Fig. 8B-C). The gene discussed is S100A14; the disease is pachyonychia congenita.