By impairing the OXPHOS and increasing mtROS, intermittent hypoxia stabilizes the interaction between HIF-1α and C/EBP-β mRNA, favoring the generation of C/EBP-β LAP isoform that up-regulates ABCB1 and ABCC1, causing chemoresistance, and down-regulates ABCA1, promoting a low anti-tumor activity of Vγ9Vδ2 T-cells. This evidence concerns the gene ABCB1 and neoplasm.