Instead of a protein-protein interaction between HIF-1α and C/EBP-β, we found that in NSCLC cells HIF-1α protein was progressively more associated to C/EBP-β mRNA in hypoxia, hypoxia/normoxia and intermittent hypoxia, favoring the production of LAP splicing isoform. The gene discussed is HIF1A; the disease is non-small cell lung carcinoma.