Although HIF-1α is known as a transcriptional regulator more than a splicing controller, one recent work reported that HIF-1α regulates the alternative splicing of SLC35A3 mRNA in pancreatic adenocarcinoma [41], paving the way to consider HIF-1α also as a post-transcriptional regulator, as it occurs in the case of C/EBP-β splicing. The gene discussed is CEBPB; the disease is pancreatic adenocarcinoma.