The ROC curve for apelin-13 as the indicator of ROP showed an area under the curve (AUC) of 0.804 (95% confidence interval [Cl], 0.702–0.907; P < 0.001), and a cut-off value of 119.6 pg/mL yielded a sensitivity of 84.8% and a specificity of 63.6%. Here, APLN is linked to retinopathy of prematurity.