It has been demonstrated recently that the telomerase substrate nucleoside precursor 6-thio-2’-deoxyguanosine (6-thio-dG) significantly impairs growth of telomerase-positive tumors in preclinical models, including neuroblastoma cell lines harboring TERT rearrangements, MYCN amplification or high TERT expression in the absence of these alterations, both in vitro and in vivo [4, 10–13]. This evidence concerns the gene MYCN and neuroblastoma.