INS and diabetes mellitus: Additionally, while the type 1 diabetes polygenic score applied in [52] could not definitively identify individuals with LADA, the score may help identify a subset of patients who are more likely to require insulin; among patients with type 2 diabetes and GAD65 autoantibodies, 48% of patients with a (30 variant [45]) type 1 diabetes polygenic score above the 50th percentile required insulin within 5 years of diabetes diagnosis, compared with 18% of patients with scores below the 5th percentile [53].