CLOCK and B-cell chronic lymphocytic leukemia: Among the remaining ten genome-wide signatures, five were previously identified in CLL and DLBCL (SBS1 and SBS5 (clock-like), SBS8 (unknown etiology), SBS9 (attributed to polymerase eta) and SBS18 (possibly damage by reactive oxygen species)); three had been only found in DLBCL (SBS2 and SBS13 (APOBEC enzymes) and SBS17b (unknown)); and two have been recently described related to treatments with melphalan34 or ganciclovir35, which were named here as SBS-melphalan and SBS-ganciclovir, respectively (Fig. 2b,c and Extended Data Fig. 4).