New alterations included deletions of CDKN1A and CDKN1B in five cases of RT associated with downregulation of their expression, one immunoglobulin (IG)-CDK6 translocation and one CCND2 mutation already present at CLL diagnosis, and CCND3-IG and MYCN-IG translocations acquired at RT in two different cases (Fig. 1d,e, Extended Data Fig. 3a,b and Supplementary Table 11). Here, CDKN1B is linked to B-cell chronic lymphocytic leukemia.