HGF and colorectal cancer: Hepatocyte growth factor (HGF) is known as a pro-cancer promotor in cancer development (Michieli et al. 1999), invasion (Date et al. 1998), metastasis and drug resistance of colorectal cancer (Liska et al. 2011; Luraghi et al. 2014) through modulating mesenchymal epithelial transition (cMET) (Michieli et al. 1999).