MTOR and cancer: The enrichment results of KEGG showed that the primary signaling pathways for differential gene enrichment in the blue module include the pathway in cancer, transcriptional mis-regulation in cancer, the PI3K-AKT signaling pathway, the Ras signaling pathway, the MAPK signaling pathway, cytokine-cytokine receptor interaction, the MAPK signaling pathway, etc. PI3K-AKT, over-activated in most breast cancers, promotes the excessive proliferation of cancer cells through the mTOR complex27.