Although the contribution of ER-endosome contacts to EGFR function during infection remains unexplored, our MCS-PRM data points to the relationship between PTPN1 and EGFR, which requires proximal interactions at ER-endosome interfaces, as a promising avenue for further elucidating the complex EGFR regulation during HCMV infectious cycles. The gene discussed is PTPN1; the disease is infection.