All four proteins at the ER-peroxisome MCS (ACBD4, ACBD5, VAP-A, VAP-B) increased in abundance throughout HCMV infection (up to 3-fold after normalization), in contrast to their slight decreases during the other infections examined (e.g., 1.5-fold, 2-fold, and 1.5-fold decreases after normalization in HSV-1, Infl. The gene discussed is ACBD5; the disease is cytomegalovirus infection.