A reduce ER-mitochondria MCS protein abundances (by up to 2-fold and 3-fold after normalization, respectively) (Fig. 1D) and that HCMV decreases ER-mitochondria interactions early in infection (Fig. 4A), our results suggest that the time-sensitive regulation of ER-mitochondria contacts may modulate STING signaling during infection. Here, STING1 is linked to infection.