Of these, APC, FHIT, LRP1B, IL21R, APC, MN1, MYH11, TP53, NRAS, CDK4, and STRN from the P-mutations set, as well as IL7R, SPEN, FUS, NR4A3 from the M-mutations set are known cancer related genes. This evidence concerns the gene NR4A3 and cancer.