Of the 443 loci, 21 were in 17 known cancer-related genes (MTOR, PDE4DIP, PDE4DIP, PDE4DIP, TPR, SF3B1, RAP1GDS1, RAP1GDS1, EBF1, NSD1, RAD21, PSIP1, BMPR1A, NT5C2, ATM, CLIP1, MYH11, USP6, USP6, RABEP1, and BCR) specified in Tier 1 (genes with documented cancer related activities) of the Cancer Gene Census database [27]. The gene discussed is PDE4DIP; the disease is cancer.