Astrogliosis, visualized by GFAP staining, has been described in the spinal cord of SMA mice (SMNΔ7) and patients with SMA, especially located in the gray matter of the ventral horn and astrocytic processes form glial bundles along the ventral roots.3, 13, 14, 15, 16. The gene discussed is GFAP; the disease is proximal spinal muscular atrophy.