However, Barnea, Madar & Froy [29], investigating the expression of genes involved in the adiponectin signaling pathway in adipose tissue and skeletal muscle (target tissue of adiponectin) in mice fed to HFD, observed changes that cause damage to the signaling and expression of these receptors, which, in turn, can lead to “resistance to adiponectin”, as happens in insulin resistance [29]. Here, ADIPOQ is linked to Insulin resistance.