To investigate whether tumor cell–derived FGFBP1 was essential for the expression of FAPα in HSCs and vessel co-option, HCT116 cells with low expression of FGFBP1 were transfected with lentivirus containing the vector or FGFBP1 sequence to generate HCT116Vector cells or FGFBP1-overexpressing HCT116FGFBP1 cells, respectively (Supplemental Figure 4, C and E). The gene discussed is FAP; the disease is neoplasm.