Additionally, immunohistochemical staining, Western blotting, and ELISA revealed that the expression of FGFBP1 in tumors or primary cultured tumor cells derived from bevacizumab-resistant HCT116 and HT-29 CRCLM xenografts was higher than in those derived from bevacizumab-sensitive HCT116 CRCLM xenografts (Figure 4, B–D). The gene discussed is FGFBP1; the disease is neoplasm.