Since MC38 allografts were intrinsically resistant to bevacizumab (Supplemental Figure 2A), this murine colon adenocarcinoma cell line was directly injected into the liver parenchyma of Fap wild-type mice (Fapfl/fl) or HSC-specific conditional Fap–knockout mice (FapΔGfap) to generate the intrinsically bevacizumab–resistant CRCLM allografts (Figure 2A and Supplemental Figure 2, B and C). Here, FAP is linked to colon adenocarcinoma.