Mechanistically, Z-GP-DAVLBH treatment reversed the development of RHGP (Figure 8, A and B), decreased the amount of co-opted sinusoidal blood vessels (Figure 8C), blocked the recruitment of Gr-1+ MDSCs, and suppressed tumor cell EMT as indicated by the increase in E-cadherin and decrease in vimentin (Supplemental Figure 12, B–D). Here, CDH1 is linked to neoplasm.