SIAH1 and cancer: In addition, SIAH1 has been implicated in cancer-related signalling pathways, including cell apoptosis (β-catenin, Sec6) [13, 14], DNA damage repair (c-Abl, HIPK2, and TRF2) [15–17] and the in vivo hypoxia response (PHD3, HIF-1a, and IL-17) [13, 18, 19].