Anatomopathological findings evidence an association between V600E mutation and temporal lobe located PXA, besides CD34 positivity and reticulin fiber formation; BRAF positivity and loss of p16 expression could be a helpful tool for differential diagnosis of PXA entity with giant-cell glioblastoma and ganglioglioma [28]. This evidence concerns the gene BRAF and pleomorphic xanthoastrocytoma.