Reductions in precursor form of SREBP-1 and mature form of SREBP-2 levels in the frontal cortex in PTU-treated Wistar rats and in the concentration of mature SREBP-2 form in the hippocampus of WKY animals were attenuated in a model of comorbid depression and hypothyroidism. The gene discussed is SREBF1; the disease is major depressive disorder.