In turn, in line with the lack of changes in the level of the active form of SREBP-1, there were also no changes in the concentration of stearoyl-CoA desaturase (SCD), an enzyme regulated by this transcription factor, which also confirms that in depression and/or hypothyroidism, biosynthesis of cholesterol rather than the fatty acids is disturbed. The gene discussed is SREBF1; the disease is major depressive disorder.