Summarizing the changes shown in the tested models, it can be said that in the depression model, changes such as lowering the level of the active form of SREBP-2, SNAP-25 and GLP-2R in the hippocampus and SNAP-25, GLP-1R and GLP-2R in the frontal cortex indicate disturbances in synaptic plasticity in both these brain regions as well as lowering molecules involved in cholesterol synthesis in the hippocampus. Here, GLP2R is linked to major depressive disorder.