In this work, we identified that UHRF1 is acetylated by TIP60 at four lysine residues in SRA-RING domain (K644, K646, K648, K650) and acetylation-deficient UHRF1 mutant impeded colon cancer cell growth through re-expression of TSGs such as Jun dimerization protein 2 (JDP2), which acts as a transcriptional regulator for cell growth and cell cycle progression (Tsai et al. 2016). Here, JDP2 is linked to malignant colon neoplasm.