We analyzed cell cycle between UHRF1 WT and 4KR and identified that 4KR affects colon cancer cell growth through re-expression of JDP2. Although we suggest that acetylation of UHRF1 can regulate expression of tumor suppressor JDP2 gene, further studies are needed to determine whether UHRF1 4KR mutant can inhibit JDP2 expression through promoter hypermethylation or other epigenetic modifications. Here, JDP2 is linked to malignant colon neoplasm.